The College of Education for Pure Sciences, Department of Chemistry, reviewed a master's thesis on the preparation and characterization of some Schiff base complexes derived from terephthalaldehyde and the evaluation of their antibacterial activity. The thesis, submitted by researcher Ayman Qader Nouri, aimed to: prepare Schiff base ligands derived from the condensation reaction of primary amines (2-aminothiazole, 2-aminobenzothiazole) with aldehydes (terephthalaldehyde, phthalaldehyde); and prepare complexes of the prepared Schiff bases by reacting them with the metal salts of Cr(III), Fe(III), Co(II), and Cu(II). Both the prepared ligands and complexes were characterized using spectroscopic methods.

This thesis included a study of the biological activity of ligands and their coordination complexes, their effect on target bacteria, and the prediction of some drug-like compounds using computer programs (ADMET, SAR).

The study involved the preparation of three Schiff base ligands derived from the condensation of aldehydes with aromatic primary amines. Their complexes were then prepared with chloride salts [Cr(III), Fe(III), Co(II), Cu(II)] and characterized using Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1H-NMR), carbon-13C-NMR, UV-Vis spectroscopy, ESI mass spectrometry, molar conductivity, magnetic susceptibility, and thermogravimetric analysis (TGA). Finally, several biological tests were performed on the prepared ligands and their coordination complexes. Its effect on certain types of bacteria, [Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative)], has been shown to be more potent than free ligands, with copper-chromium complexes being the most prominent and effective among them. Computer studies (ADMET, SAR) demonstrate that these compounds possess high antibacterial activity

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